email: m.konarska@dev.dev.cent.uw.edu.pl/en
phone: +48 22 55 43705
room: 04.165
Laboratory of RNA Biology (Group Leader)
phone: +48 22 55 43705
room: 04.165
Laboratory of RNA Biology (Group Leader)
| Education and degrees: | |
| 1979 | M.Sc. in Biology, University of Warsaw |
| 1983 | Ph.D. in Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw |
| 2000 | Dr hab., Institute of Biochemistry and Biophysics, Warsaw, Poland |
| Positions: | |
| since 10.2018 | Deputy Director “Regenerative Mechanisms for Health”, International Research Agenda Unit (“ReMedy”) |
| since 2015 | Date Professor and Head of Laboratory of RNA Biology, CeNT UW, Warsaw and Professor Emeritus, The Rockefeller University, New York |
| 2009-2015 | Evelyn Gruss-Lipper Professor and Head of Laboratory, The Rockefeller University |
| 2000-2015 | Professor and Head of Laboratory, The Rockefeller University |
| 1994-2000 | Associate Professor and Head of Laboratory, The Rockefeller University |
| 1989-1994 | Assistant Professor and Head of Laboratory, The Rockefeller University |
| 1987-1989 | Research Associate in the laboratory of Prof. Phillip A. Sharp, Center for Cancer Research, MIT, Cambridge, MA |
| 1984-1986 | Postdoctoral Fellow in the laboratory of Prof. Phillip A. Sharp, Center for Cancer Research, MIT, Cambridge, MA |
| 1979-1983 | Ph.D. Student in the laboratory of Prof. Witold Filipowicz, Polish Academy of Sciences, Institute of Biochemistry and Biophysics, Warsaw |
| 1981,82 and 83 (total of nine months) |
Research Fellow in the laboratory of Prof. Hans J. Gross, University of Würzburg, Institute of Biochemistry, Würzburg, West Germany |
| 1979 | Research Fellow in the laboratory of Prof. Hans J. Gross, Max-Planck Institute for Biochemistry, Martinsried, West Germany |
| Memberships and Awards: | |
| 2017 | Member of the Academia Europaea |
| 2017 | Member of the European Molecular Biology Organization |
| 2016 | Corresponding Member of the Polish Academy of Science |
| 1992-1997 | The Monique Weill-Caulier Career Scientist Award |
| 1987-1994 | The Lucille P. Markey Scholar Award |
| 1983-1986 | The Jane Coffin Childs Memorial Fund Postdoctoral Fellowship |
| 1985 | The Jakub Karol Parnas Award of the Polish Biochemical Society |
| 1983 | The Polish Academy of Sciences – Scientific Secretary Award |
| 1982 | The Polish Academy of Sciences – Biological Sciences Section Award |
Selected publications:
- Konarska, M.M., Filipowicz, W., Domdey, H. and Gross, H.J. Formation of a 2′-phosphomonoester, 3′,5′-phosphodiester linkage by a novel RNA ligase in wheat germ. Nature 293, 112-116 (1981).
- Konarska, M.M., Padgett, R.A. and Sharp, P.A. Recognition of cap structure in splicing in vitro of mRNA precursors. Cell 38, 731-736 (1984).
- Konarska, M.M., Grabowski, P.J., Padgett, R.A. and Sharp, P.A. Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors. Nature 313, 552-557 (1985).
- Konarska, M.M., Padgett, R.A. and Sharp, P.A. Trans-splicing of mRNA precursors in vitro. Cell 42, 165-171 (1985).
- Konarska, M.M. and Sharp, P.A. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell 49, 763-774 (1987).
- Konforti, B.B., Koziołkiewicz, M.J. and Konarska, M.M. Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly. Cell 75, 863-873 (1993).
- Siatecka, M., Reyes, J.L. and Konarska, M.M., Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center. Genes & Dev. 13,1983-1993 (1999).
- Query, C.C. and Konarska, M.M. Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Molecular Cell 14, 343-354 (2004).
- Liu, L., Query, C.C. and Konarska, M.M. Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nature Struct. Mol. Biol. 14, 519-26 (2007).
- Smith, D.J., Konarska, M.M. and Query, C.C. Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast. Molecular Cell 34, 333-343 (2009).
- Smith, D.J., Query, C.C., and Konarska, M.M. trans-Splicing to Spliceosomal U2 snRNA Suggests Disruption of Branch Site-U2 Pairing during Pre-mRNA Splicing. Mol Cell 2007 Jun 22;26(6):883-90.
- Query, C.C. and Konarska, M.M. CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome. RNA 18, 1001-1013 (2012).
